General Anestesi pada Pasien Laparatomi Tumor Hepar

Authors

  • Muhammad Ezyra Widya Aqshal Universitas Malikussaleh
  • Anna Millizia Universitas Malikussaleh

DOI:

https://doi.org/10.62383/aksinyata.v3i1.2843

Keywords:

Anesthesia, HCC, Liver Tumor, Surgery, Tumor Resection

Abstract

Chronic liver disease is a significant health problem and places a significant burden on healthcare services. Deaths from complications of chronic liver disease (cirrhosis and cancer) account for approximately 3.5% of all deaths worldwide each year. Hepatocellular carcinoma (HCC) is a primary liver tumor, accounting for 90% of all liver tumors. Due to limitations in liver transplantation, liver resection is considered the treatment of choice for HCC patients with a single tumor and sufficient liver function reserve. Liver resection and transplantation are the only curative treatment options available for HCC patients. Surgical procedures require anesthesia. General anesthesia is the preferred method for liver tumor resection. There are five main classes of anesthetic agents: intravenous (IV) anesthetics, inhalational anesthetics, IV sedatives, synthetic opioids, and neuromuscular blocking agents. Estimated health risks depend on the extent or severity of liver disease, the nature and timing of surgery, the type of anesthesia, and other comorbidities.

References

Asafo-Agyei, K. O., & Samant, H. (2023). Hepatocellular carcinoma. StatPearls Publishing, 1–14.

Bedewy, A., & El-Kassas, M. (2023). Anesthesia in patients with chronic liver disease: An updated review. Egyptian Journal of Anaesthesia, 47(8), 1–10.

Budiana, M. I. Z., Mixropa, S., & Burhan, A. (2024). Hubungan status fisik American Society of Anesthesiologists (ASA) dengan Bromage score di rumah sakit. Jurnal Ilmu Kesehatan Mandira Cendikia, 3, 377–384.

Dabke, T., Scott, T. E., & Taylor, B. (2026). Impact of preoperative fasting duration on perioperative complications in elective paediatric procedures: A systematic review and meta-analysis. British Journal of Anaesthesia, 136(1), 158–166. https://doi.org/10.1016/j.bja.2025.10.037

Darwish, D., Kumar, P., Urs, K., Dave, S., & Green, T. (2024). Inhaled anesthetics: Beyond the operating room. Journal of Clinical Medicine, 1–18.

Folino, T. B., Muco, E., Safadi, A. O., & Parks, L. J. (2023). Propofol. StatPearls Publishing, 8–13.

İster, G., Erbaş, D. H., & Aslan, F. E. (2025). The effect of prolonged fasting before surgery on pain and anxiety. Journal of PeriAnesthesia Nursing, 40(2), 377–380.

Jadaun, S. S., & Saigal, S. (2022). Surgical risk assessment in patients with chronic liver diseases. Journal of Clinical and Experimental Hepatology, 12(4), 6–11.

Khoerunnissa, Fitri, S. U. R., & Harun, H. (2023). Manajemen nyeri pada pasien dengan hepatoma (hepatocellular carcinoma): Studi kasus. SENTRI: Jurnal Riset Ilmiah, 2(7), 2612–2619.

Kotani, Y., Pruna, A., Turi, S., Borghi, G., Lee, T. C., Zangrillo, A., Landoni, G., & Pasin, L. (2023). Propofol and survival: An updated meta-analysis of randomized clinical trials. Critical Care, 27, 1–10. https://doi.org/10.1186/s13054-023-04431-8

Liu, Y., Fu, H., & Wang, T. (2022). Neuroinflammation in perioperative neurocognitive disorders: From bench to the bedside. CNS Neuroscience & Therapeutics, 28(4), 484–496. https://doi.org/10.1111/cns.13794

Madina, A., & Millizia, A. (2024). Manajemen anestesi operasi total thyroidectomy pada pasien struma multinodosa: Laporan kasus. Jurnal Anestesiologi Klinis, 2(3).

Rajaretnam, N., Okoye, E., & Burns, B. (2023). Laparotomy. StatPearls Publishing, 6–11.

Shehta, A., Elsabbagh, A. M., Medhat, M., Farouk, A., Monier, A., Said, R., Salah, T., Elshobari, M., Fouad, A., & Elghawalby, A. N. (2024). Impact of tumor size on the outcomes of hepatic resection for hepatocellular carcinoma: A retrospective study. BMC Surgery, 24, 1–13. https://doi.org/10.1186/s12893-023-02296-w

Si, S., Zhao, X., Su, F., Lu, H., Zhang, D., Sun, L., Wang, F., & Xu, L. (2023). New advances in clinical application of neostigmine: No longer focusing solely on increasing skeletal muscle strength. Frontiers in Pharmacology, 14, 1–8. https://doi.org/10.3389/fphar.2023.1227496

Smith, G., Cruz, J. R. D., Rondeau, B., & Goldman, J. (2023). General anesthesia for surgeons. StatPearls Publishing, 1–5.

Vahabi, S., Beiranvand, S., Kiabi, F. H., & Rastad, H. (2024). Complications after general anesthesia between female and male genders in the first 24 hours after surgery. The Open Public Health Journal, 17, 1–10. https://doi.org/10.2174/0118749445328813241001023931

Yi, Q., Wang, L., & Anesthesia, P. (2023). Perspectives on propofol anesthesia research: The important role of subcortical structures in dynamic transformations of propofol’s neural circuits. Journal of Anesthesia and Translational Medicine, 0(April), 11–15. https://doi.org/10.58888/2957-3912-2023-05-24

Zhao, R., Xu, X., Sun, L., & Zhang, G. (2023). Long-term effect of anesthesia choice on patients with hepatocellular carcinoma undergoing open liver resection. Frontiers in Oncology, 13, 1–11. https://doi.org/10.3389/fonc.2022.960299

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Published

2026-01-22

How to Cite

Muhammad Ezyra Widya Aqshal, & Anna Millizia. (2026). General Anestesi pada Pasien Laparatomi Tumor Hepar. Aksi Nyata : Jurnal Pengabdian Sosial Dan Kemanusiaan, 3(1), 147–156. https://doi.org/10.62383/aksinyata.v3i1.2843